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AI-native biology, beyond the announcements
What are AI-native biotech companies betting on, how do their approaches differ, and what changes as the work meets reality?
A research series on the companies rebuilding biological discovery around AI: what they are betting on, how their approaches differ, and what changes as the work meets reality.
AI-native biotechDrug discoveryProtein structure & functionAI & machine learning
Featured: October 2026
RESEARCH RECORD
Records on this thread
6 filed under this thread, 0 linked through shared tags.
- 2025-06-03
AI-native biology, beyond the announcements · Paper · Nature Medicine
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial
Randomized, placebo-controlled phase 2a trial of rentosertib, a TNIK inhibitor described as AI-generated, in idiopathic pulmonary fibrosis.
- 2024-11-20
AI-native biology, beyond the announcements · Company
Recursion completes business combination with Exscientia
Two AI-driven drug discovery companies combined, with Exscientia becoming a wholly owned subsidiary of Recursion.
- 2024-05-08
AI-native biology, beyond the announcements · Release · Nature
Accurate structure prediction of biomolecular interactions with AlphaFold 3
Predicts joint structures of complexes of proteins, nucleic acids, small molecules, ions and modified residues.
- 2023-07-11
AI-native biology, beyond the announcements · Release · Nature
De novo design of protein structure and function with RFdiffusion
A general diffusion-model framework for de novo protein design, including binder design and higher-order symmetric architectures.
- 2021-11
AI-native biology, beyond the announcements · Company
Isomorphic Labs announced as a new Alphabet company
A DeepMind spin-out set up to "reimagine the entire drug discovery process from first principles with an AI-first approach", building on AlphaFold2.
- 2021-07-15
AI-native biology, beyond the announcements · Release · Nature
Highly accurate protein structure prediction with AlphaFold
AlphaFold predicts protein structures with high accuracy from sequence.
Related background
Selected publications that share a tag with this thread. They are background and do not shape it.
- 2001 · NeuronStructure of the RCK Domain from the E. coli K+ Channel and Demonstration of Its Presence in the Human BK Channel
- 2010 · ScienceStructure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 Å Resolution
- 2023 · BMC GenomicsUsing published pathway figures in enrichment analysis and machine learning
- 2024 · Cell ReportsMachine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models